The quarter-inch rule, and why it's smaller than intuition
The single most useful fact in this whole question is the size threshold: a house mouse can pass through any opening its skull fits through, which in practice means roughly a quarter inch, about the width of a standard pencil. That's smaller than most people picture when they imagine a mouse-sized gap, and it's exactly why homeowners are often surprised that a house they consider well-sealed still has an active mouse problem.
This isn't a soft guideline — it reflects a mouse's actual skeletal structure, since the skull is rigid while the rest of the body can compress. CDC frames the same fact in consumer terms: seal any hole the width of a pencil or larger. That's the number to actually measure against, not a general sense of whether a gap "looks small."

